Our Tangential Flow Filtration Systems are designed and built to the specific requirements of microfiltration, ultrafiltration, or nanofiltration applications. Our process development team works closely with the client to generate a system specification that meets their processing requirements. Typical TFF applications include fermentation cell culture clarification, diafiltration, protein purification/concentration, and blood fractionation processing. 

Each system is designed to maximize product recovery, maximize yield and minimize its overall footprint. Ease of use for the operator is always paramount during the design layout process. Our custom TFF Systems can vary in size and complexity. Systems are designed to incorporate any commercially available membrane configurations and molecular weights. Our expertise ranges from manual benchtop systems to large (>200m2), fully factory integrated production systems. No job is too small, and no job is too large! 

Our Inline Dilution System (ILD) allows clients to prepare a continuous supply of high accuracy dilute solutions over a wide range of concentrations in support of Process and Clean-In-Place operations. The system design includes the option to dilute solution concentrations directly by volume using mass flow-meters and/or conductivity measurements. The system is suitable for all concentrations, reduces the storage requirements for hazardous chemicals, provides cost savings over purchase of multiple discrete concentrations, provides process simplification and increased flexibility.

Typical capabilities include:

• Dilute 8N NaOH to 5N, 0.5N and 0.1N
• Final dilution accuracy <1.5% based on flowrate while operating in closed loop flow control
• Final dilution flow rate ~45 LPM @ 30 psig at skid outlet 

Exentec designs and fabricates custom sanitary filter holders for the biopharmaceutical industry. Our filter holders are customized in a variety of ways to meet your flow needs. Typical modifications include In-Line/T-Line, number of cartridges, cartridge length, inlet/outlet connections and vent/drain configurations. ASME stamped and cartridge code holders are available for sanitary and industrial applications. Our Design Team will generate a detailed holder drawing and spare parts list. Our Quality Team ensures that our holders meet all surface finish, code, dimensional, and configuration specifications.

In addition, we design and fabricate filter holder skids for mobile applications. The same principles which apply to system design are incorporated within our filter holder skid layouts. Care is taken to minimize the overall skid footprint and facilitate cleanability. Call with your specific product needs.